Table 2.
1H (600 MHz) and 13C (150 MHz) NMR spectroscopic data for 7 and 8 (DMSO–d6, 298 K).
| Position | Phragamide A (7) | Phragamide B (8) | ||
|---|---|---|---|---|
| δH (Mult., J in Hz) | δC, Mult. | δH (Mult., J in Hz) | δC, Mult. | |
| 1 | 2.15 (s) | 30.0, CH3 | ||
| 2 | 168.1, C | 201.9, C | ||
| 3 | 4.65 (s) | 81.8, CH | 3.76 (br s) | 52.9, CH2 |
| 4 | 169.1, C | |||
| 5 | 166.0, C | |||
| 6 | 4.10 (br s) | 57.5, CH | 176.7, C | |
| 7 | 4.05 (m) | 68.4, CH | 2.50 (m) | 41.8, CH |
| 8 | 1.14 (d, 6.2) | 18.6, CH3 | 1.51–1.33 (m) | 26.3, CH2 |
| 9 | 1.93 (m) | 38.3, CH | 0.81 (t, 7.6) | 10.9, CH3 |
| 10 | 1.41–1.28 (m) | 24.5, CH2 | 0.98 (d, 6.9) | 16.2, CH3 |
| 11 | 0.87 (t, 7.2) | 11.8, CH3 | ||
| 12 | 0.92 (d, 7.5) | 14.7, CH3 | ||
| 1-NH | 8.36 (br s) | |||
| 5-NH | 10.76 (br s) | |||
| 7-OH | 5.45 (brs) | |||