Skip to main content
. 2021 Apr 20;22(8):4291. doi: 10.3390/ijms22084291

Figure 3.

Figure 3

Isoflurane conditioning attenuates SAH-induced microvessel thrombosis with and without EX-527. Wild-type mice were subjected to sham surgery or endovascular perforation SAH and treated with vehicle (DMSO+1.2% cyclodextrin+PBS1X) or EX-527 (10mg/kg) diluted with vehicle. Two out of four groups were exposed to 2% isoflurane for one hour (postC), one hour after SAH, and one isoflurane group out of two received a single dose of EX-527 immediately after SAH. Microvessel thrombosis was assessed on day 3. Data indicate mean±SEM. (A) ** p < 0.01 sham vs. SAH, ** p < 0.01 SAH vs. SAH-postC, SAH-postC+EX-527, p > 0.05 SAH-postC, SAH-postC+EX-527, by ANOVA and Newman–Keuls multiple comparisons test. (n = 5) ns—nonsignificant. (B) Representative images for microvessel thrombosis. ISO—Isoflurane. Scale bar = 100 μm.