Table 1.
Fold changes in top-10 upregulated and downregulated genes.
| Gene Symbol | Gene Description | 1 Fold Change(log2) |
|---|---|---|
| AQP3 | Aquaporin 3 (Gill blood group) | 62.82 |
| TPPP3 | Tubulin polymerization-promoting protein family member 3 | 24.03 |
| S100P | S100 calcium binding protein P | 14.16 |
| FGL1 | Fibrinogen-like 1 | 13.25 |
| SNORA17 | Small nucleolar RNA, H/ACA box 17 | 12.62 |
| SPDEF | SAM pointed domain containing ETS transcription factor | 8.35 |
| AGR2 | Anterior gradient 2 | 8.11 |
| LXN | Latexin | 7.43 |
| PDK4 | Pyruvate dehydrogenase kinase, isozyme 4 | 7.20 |
| CP | Ceruloplasmin (ferroxidase) | 6.94 |
| MARCH4 | Membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase | −6.93 |
| RPL21 | Ribosomal protein L21 | −7.08 |
| FOSL1 | Fos-related antigen 1 isoform 2 | −7.22 |
| LINC00707 | Long intergenic non-protein coding RNA 707 | −7.49 |
| CYR61 | Cysteine-rich, angiogenic inducer, 61 | −8.17 |
| ANKRD1 | Ankyrin repeat domain 1 (cardiac muscle) | −8.26 |
| MIR663A | MicroRNA 663a | −8.46 |
| IL32 | Interleukin 32 | −9.88 |
| IL11 | Interleukin 11 | −10.85 |
| EDN2 | Endothelin 2 | −12.28 |
1 Fold changes were calculated as the ratio of A549 spheroids to A549 2D cells.