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. 2021 Apr 12;12:632492. doi: 10.3389/fendo.2021.632492

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Copyright © 2021 Chen, Liu, Hu, Zhang, Shi and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow cytometric analysis confirmed declined frequencies of Th17 and Treg cells in pGD patients. (A, C) Representative flow cytometry plots of (A) Th17 cells (IL17A+) gated in CD3+CD8− T cells and (C) Treg cells (CD25+Foxp3+) gated in CD4+ T cells from pGD (left) and nGD (right) patients respectively. The numbers denote the percentage of cells in each rectangle gate. (B, D) Whisker plots showed percentage of (B) Th17 cells and (D) Treg cells in CD4+ T cells in pGD (triangle, N = 12) and nGD (circle, N = 14) patients. Data were exhibited as mean with SD with individual values. pGD, persistent Graves’ disease; nGD, newly diagnosed Graves’ disease; SD, standard deviation.