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. 2021 Apr 12;12:632492. doi: 10.3389/fendo.2021.632492

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Copyright © 2021 Chen, Liu, Hu, Zhang, Shi and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Specific genes expression in pGD compared with nGD patients. (A–D) Whisker plots indicated normalized gene expression associated with (A) inflammation (B) chemotaxis (C) Th17 cells (D) Treg cells between pGD (red, N = 13) and nGD (blue, N = 20) samples. Data were exhibited as mean with SD with individual values. (E) The hierarchical clustering of 13 pGD and 20 nGD patients by differentially expressed immune related genes. The heatmap showed, for each gene, the scaled expression in each patient. pGD, persistent Graves’ disease; nGD, newly diagnosed Graves’ disease; SD, standard deviation; FPKM, fragments per kilobase of exon per million fragments mapped.