Figure 5.

Robust inflammatory and cytokine responses pathways were prominent in pGD patients with lower FOXP3 and IKZF2 expression. (A, C) Gene set enrichment analysis (GSEA) showed complement, inflammatory response, KRAS signaling up pathways in hallmark gene set were most enriched in pGD patients with (A) lower FOXP3 and (C) lower IKZF2 expression. (B, D) GSEA showed cytokine-cytokine receptor interaction pathway in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was obviously enriched in pGD patients with (B) lower FOXP3 and (D) lower IKZF2 expression. pGD, persistent Graves’ disease.