Table 1.
Clinical characteristic of enrolled pGD and nGD patients.
| Characteristic | Persistent GD (n=20) | Newly diagnosed GD (n=20) | P value |
|---|---|---|---|
| Basal clinical characteristics | |||
| Gender (Female/male) | 18/2 | 16/4 | 0.376# |
| Age (years) | 38.3±9.5 | 40.4±10.8 | 0.517 |
| Family history of autoimmune thyroid disease (Y/N) | 3/17 | 2/18 | 0.633# |
| ATD treatment duration (years) | 10.28±0.96 | NA | NA |
| Smoking (Y/N) | 6/14 | 9/11 | 0.327# |
| Thyroid function | |||
| TSH (μmol/L) | 0.115(0.007-2.480) | 0.007(0.007-2.710) | 0.067* |
| FT4 (pmol/L) | 21.00(11.00-90.90) | 34.60(11.30-200.00) | 0.036* |
| TT4 (pmol/L) | 12.35±6.07 | 20.64±9.06 | 0.003 |
| TGAb (%) | 31.20(3.97-72.70) | 16.30(2.24-50.26) | 0.134* |
| TMAb (%) | 20.24±12.13 | 12.24±9.86 | 0.177 |
| TRAb (U/L) | 18.68±2.70 | 19.53±3.20 | 0.840 |
| Other laboratory tests | |||
| PLT (10^9/L) | 239.69±53.38 | 229.53±43.42 | 0.459 |
| WBC (10^9/L) | 5.46±1.51 | 6.19±1.38 | 0.122 |
| LYMPH (10^9/L) | 1.77(0.92-2.59) | 1.94(0.93-3.14) | 0.119* |
| MONO (10^9/L) | 0.31±0.09 | 0.43±0.17 | 0.024 |
| NEUT (10^9/L) | 3.30±1.25 | 3.66±1.20 | 0.427 |
| EO (10^9/L) | 0.04(0.00-0.14) | 0.07(0.00-0.22) | 0.515* |
| BASO (10^9/L) | 0.02(0.00-1.00) | 0.02(0.00-0.05) | 0.553* |
| PBMC (10^9/L) | 1.86±0.76 | 2.45±0.64 | 0.011 |
| CHOL (mmol/L) | 3.99±0.59 | 3.68±1.13 | 0.733 |
#P value by x2-test.
*P value by Mann-Whitney U-test. The rest of P value were by Student’s t-test.
GD, Grave’s disease; TSH, Thyroid stimulating hormone; FT4, Free thyroxine; TT4, Total thyroxine; TGAb, Anti-thyroglobulin auto-antibodies; TMAb, Anti-thyroid microsomal auto-antibodies; TRAb, and anti-thyroid stimulating hormone receptor autoantibodies; PLT, Platelet; WBC, White blood cell; LYMPH, Lymphocyte; MONO, Monocyte; NEUT, Neutrophil; EO, Eosinophil; BASO, Basophil; PBMC, Peripheral blood mononuclear cell; CHOL, Cholesterol. Data were presented as mean±S.D. or median(range).