TABLE 3.

Studies of embryo development after silencing of ADAMTS1.

	si-Ctrl (n = 48)	si-ADAMTS1 (n = 48)	p-value
Development time to morula stage (h)	68.21 ± 2.66	77.05 ± 3.09	0.037
Good-quality embryo rate (%)	76.3	65.8	0.312
Morula formation rate (%)	47.4	47.4	1.000
Blastocyst formation rate (%)	28.9	31.6	0.803
Good-quality blastocyst rate (%)	27.3	25.0	0.901

The development time to morula stage is calculated from the time of siRNA injection. Good-quality embryo rate (%) = (number of D3 good-quality embryos/number of cleaved embryos) × 100; Morula formation rate (%) = (number of morulae/number of embryos cultured) × 100; Blastocyst formation rate (%) = (number of blastocysts/number of embryos cultured) × 100; Good-quality blastocyst rate (%) = (number of good-quality blastocysts/number of blastocysts) × 100. p < 0.05 was considered statistically significant.