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Dose-response curve of topotecan from the tetramethyl rhodamine methyl ester (TMRM) assay with ReNCell VM cells on the 384-pillar plate. The mitochondrial membrane potential (MMP) signals were obtained by calculating the mean and standard deviation (error bars) of six biological replicates, which were normalized with the signals from the DMSO alone control. The IC50 value is the compound concentration that affects MMP activity by 50%.
