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. 2021 Apr 12;9:657623. doi: 10.3389/fcell.2021.657623

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Copyright © 2021 Chen, Ma, Deng, Lin, Gao, He, Lu, Pi, He, Zhou, Zhang, Yu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Radiofrequency electromagnetic fields (RF-EMF) exposure decreased CREB phosphorylation through EPHA5. (A) RF-EMF exposure inhibited CREB phosphorylation in NSC-derived cells. **p < 0.01 by Student t-test. (B) RF-EMF exposure reduced the phosphorylation of CREB in Neuro-2A cells. **p < 0.01 by Student t-test. (C) EPHA5 silencing decreased CREB phosphorylation in NSC-derived cells. **p < 0.01 by Student t-test. (D) EPHA5 recombinant protein treatment rescued CREB phosphorylation after RF-EMF exposure in NSC-derived cells. *p < 0.05, and **p < 0.01 by Student t-test. (E) RF-EMF exposure increased the GTP-bound RhoA level. (F) EPHA5 silencing increased the GTP-bound RhoA level. (G) EPHA5 recombinant protein treatment reversed the GTP-bound RhoA level after RF-EMF exposure.