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(A) First step of hair follicle (HF) induction. Through an unknown trigger, intracellular β-catenin accumulates in the dermis, activating various transcription factors in the nucleus. (B) Next step of HF induction. Intracellular dermal β-catenin induces expression of WNT ligands that activate neighboring cells and eventually those in the epithelial layer. Epithelial WNT activation results in a high concentration of intracellular β-catenin in the epidermis.
