Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 12;9:661787. doi: 10.3389/fcell.2021.661787

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 de Groot, Ulrich, Gho and Huisman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Formation of the dermal condensate (DC). FGF20 is the first epidermal signal that marks the start of the organogenesis phase. FGF20 induces DC formation in the dermis. DC cells produce inhibitory factors such as BMP4 to fine tune the borders and specification of the DC. At the apical side of the DC, high concentrations of Noggin block the inhibitory signaling of BMP4. Meanwhile, the placode continues to mature through the FGF, WNT/β-catenin, and EDA/EDAR/NF-κB axis. Red indicates inhibitory signaling, and green indicates stimulatory signaling.