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Influence of Sonic hedgehog (SHH) on placode formation. SHH affects both the epithelial and mesenchymal layer of the developing hair follicle. SHH aids in the proliferation of the hair placode in the epithelial layer through cyclin D1. In the dermal condensate (DC), SHH primarily induces higher Noggin expression, creating a positive feedback loop for the downgrowth of the hair placode.
