Table 5.
Sensitivity Analysis: Screening Cost per Incident of Visual Impairment or Blindness Prevented Under Various Scenarios
| Scenario | Screening Cost per Incident Prevented, $ per Incident | |
|---|---|---|
| Visual Impairment | Blindness | |
| Screen between ages 50 and 59 years, base case | 71 000 | 99 000 |
| Additional screening at ages 60 and 70 years | 82 000 | 132 000 |
| Incomplete patient follow-up after positive FDT results, 50% follow-up | 108 000 | 167 000 |
| Low treatment efficacy (hazard ratio for glaucoma progression = 0.87) | 281 000 | 393 000 |
| High treatment efficacy (hazard ratio for glaucoma progression = 0.49) | 38 000 | 52 000 |
| Low FDT sensitivity (0.65) and specificity (0.73) | 110 000 | 130 000 |
| High FDT sensitivity (0.99) and specificity (0.97) | 57 000 | 94 000 |
| Less expensive FDT examination ($45) | 42 000 | 58 000 |
| More expensive FDT examination ($110) | 114 000 | 177 000 |
Abbreviation: FDT, frequency-doubling technology.