Table 1.
Demographic, cognitive and clinical characteristics of sample.
| Non-carriers | Cognitively Unimpaired Carriers | Symptomatic Carriers | All Carriers | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| M(SD) | pa | M(SD) | pb | M(SD) | M(SD) | pc | |||||
| Male n = 9 | Female n = 13 | Male n = 8 | Female n = 11 | Male n = 3 | Female n = 8 | Male n = 11 | Female n = 19 | ||||
| Age (years) | 30.89 (8.81) | 34.21 (8.88) | .449 | 31.13 (9.75) | 32.82 (8.33) | .545 | 47.00 (3.00) | 47.87 (5.08) | 35.45 (11.10) | 39.16 (10.34) | .838 |
| Education (years) | 12.00 (3.16) | 10.83 (3.41) | .498 | 12.13 (3.23) | 12.36 (2.06) | .075 | 6.00 (2.65) | 9.75 (3.58) | 10.45 (4.11) | 11.26 (3.02) | .121 |
| MMSE | 29.67 (.50) | 29.77 (.44) | .459 | 29.88 (.35) | 29.91 (.30) | .904 | 25.00 (1.00) | 23.88 (4.05) | 28.55 (2.34) | 27.37 (3.97) | 1.00 |
| CERAD Total | 79.44 (6.08) | 80.79 (7.14) | .430 | 79.75 (6.34) | 88.00 (9.18) | .047* | 45.67 (5.77) | 39.12 (11.19) | 70.45 (16.98) | 67.42 (26.65) | .303 |
| CERAD Word List – Learning | 18.56 (2.51) | 19.79 (3.21) | .280 | 19 (2.51) | 21.64 (2.91) | .030* | 7.67 (2.52) | 5.88 (3.27) | 15.91 (5.80) | 15 (8.53) | .469 |
| CERAD Word List – Delayed Recall | 7.00 (1.32) | 7.43 (1.50) | .496 | 7.38 (.52) | 8.00 (1.61) | .230 | 2.00 (1.00) | .88 (1.13) | 5.91 (2.59) | 5.00 (3.87) | .138 |
| CERAD Word List – Recognition | 9.78 (.67) | 9.86 (.53) | .747 | 9.88 (.35) | 9.91 (.30) | .816 | 6.00 (1.00) | 4.25 (3.37) | 8.82 (1.89) | 7.53 (3.56) | .301 |
| Hippocampal Volume × 103 | 5.52 (.19) | 5.68 (.48) | .378 | 5.46 (.58) | 5.66 (.31) | .56 | 3.72 (.45) | 4.22 (1.11) | 4.98 (.96) | 5.05 (1.03) | .540 |
Note: M = Mean; SD = Standard Deviation; MMSE = Mini Mental State Exam; CERAD = Consortium to Establish a Registry for Alzheimer’s Disease.
a
p-value calculated for Mann-Whitney test for males versus females in matched non-carriers.
b
p-value calculated for Mann-Whitney test for males versus females in cognitively intact PSEN1 mutation carriers.
c
p-value calculated for Mann-Whitney test for males versus females across all PSEN1 mutation carriers (including cognitively unimpaired and symptomatic carriers).
*
p<0.05.*. Group differences significant at the 0.05 level (2-tailed).