. Author manuscript; available in PMC: 2021 Apr 26.

Published in final edited form as: J Alzheimers Dis. 2020;77(4):1743–1753. doi: 10.3233/JAD-200723

Table 2.

Correlation of age, cognitive measures and neurodegeneration in cognitively unimpaired PSEN1 mutation carriers, across all PSEN1 mutation carriers and non-carriers.

	Cognitively Unimpaired Carriers
	Male n = 8		Female n = 11
	r_s	p^a	r_s	p^b	Z	p^c
CERAD Total	.15	.720	.05	.894	.18	.859
CERAD Word List – Learning	.27	.512	−.27	.427	.97	.331
CERAD Word List – Delayed Recall	.34	.407	.16	.644	.34	.735
CERAD Word List – Recognition	.50	.206	.16	.644	.68	.496
Hippocampal Volume	−.23	.586	−.43	.189	.40	.692
	All Carriers
	Male n = 11		Female n = 19
	r_s	p^a	r_s	p^b	Z	p^c
CERAD Total	−.55	.081	−.68	.001^*	.49	.626
CERAD Word List – Learning	−.52	.103	−.76	.000^*	.97	.332
CERAD Word List – Delayed Recall	−.51	.107	−.66	.002^*	.53	.595
CERAD Word List – Recognition	−.58	.060	−.62	.005^*	.14	.885
Hippocampal Volume	−.71	.015^*	−.66	.002^*	−.22	.827
	Non-Carriers
	Male n = 9		Female n = 14
	r_s	p^a	r_s	p^b	Z	p^c
CERAD Total	−.01	.983	−.02	.931	.02	.984
CERAD Word List – Learning	.23	.558	.23	.427	.00	1.00
CERAD Word List – Delayed Recall	−.23	.553	.06	.825	−.58	.562
CERAD Word List – Recognition	.00	1.00	−.38	.181	.78	.430
Hippocampal Volume	−.13	.732	−.19	.507	.12	.903

Note: CERAD = Consortium to Establish a Registry for Alzheimer’s Disease; Hippocampal Volume = Hippocampal Volume Ratio; r_s = Spearman’s rho coefficient; Z = Z statistics.

p-value calculated for Spearman correlation in males.

p-value calculated for Spearman correlation in females.

p-value calculated for Fisher exact test comparing Spearman’s rho in males and females.

p<0.05.*. Group differences significant at the 0.05 level (2-tailed).