Table 1:

Guideline Recommended Doses and ESETT Protocol Eligibility Criteria (adapted from Sathe AG, Tillman H, Coles LD, et al. Underdosing of Benzodiazepines in Patients with Status Epilepticus Enrolled in Established Status Epilepticus Treatment Trial. Acad Emerg Med 2019;0(8):940–3).

		Guideline Recommended Doses per Administration*	ESETT Eligibility Criteria for Minimally Adequate Cumulative Dose**
Drug	Route		Dose for ≥ 32 kg Patients (mg)	Dose for < 32 kg Patients (mg/kg)
Diazepam	IV Rectal	0.15-0.2 mg/kg/dose, max: 10 mg/dose, may repeat dose once If IV route not available, then 0.2-0.5 mg/kg/dose, max: 20 mg/dose	10	0.3
Lorazepam	IV	0.1 mg/kg/dose, max: 4 mg/dose, may repeat dose once	4	0.1
Midazolam	IV	IM Dosing: 10 mg for > 40 kg, 5 mg for 13-40 kg	10	0.2
	IM		10	0.3
	IN/Buccal	Dosing not specified

^*Meierkord H et al., European Journal of Neurology, 2006; 13(5): 445-450; Brophy GM et al. ,Neurocritical Care 2012;17(1):3–23 and Glauser T et al., Epilepsy Currents, Vol. 16, No. 1 (January/February) 2016 pp. 48–61

^**Cut-off criteria for the transmucosal routes were the same as those for the intravenous route