Table 3.
Age- and Sex-Adjusted Incidence Rate (IR) and Hazard Ratio (HR), with 95% Confidence Interval (95% CI), of Hip Fracture (HF) According to Use of AED
| Incident HF (N= 1028) | Age- and Sex- Adjusted IR/100 Person-Years (95% CI) | Matched HRa (95% CI) | Propensity Score Adjusted HR (95% CI) | IPTW HRb (95% CI) | Stabilized IPTW HRc (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | ||||||||||
| Non-users | 673 | 65.5 | 1.8 (1.6; 1.9) | Reference | Reference | Reference | Reference | ||||
| Users | 355 | 34.5 | 2.0 (1.8; 2.2) | 1.24 | (1.07; 1.44) | 1.10 | (0.93; 1.29) | 1.17 | (1.05; 1.30) | 1.16 | (1.00; 1.36) |
| Duration of used, e - any AED (weeks) | |||||||||||
| Short (<14) | |||||||||||
| Non-users | 57 | 8.5 | 0.1 (0.1; 0.2) | Reference | Reference | Reference | Reference | ||||
| Users | 112 | 31.6 | 0.6 (0.5; 0.7) | 4.30 | (3.13; 5.92) | 3.98 | (2.84; 5.57) | 3.64 | (2.90; 4.58) | 3.62 | (2.65; 4.93) |
| Medium (14 to <64) | |||||||||||
| Non-users | 161 | 23.9 | 0.4 (0.3; 0.5) | Reference | Reference | Reference | Reference | ||||
| Users | 114 | 32.1 | 0.9 (0.7; 1.1) | 2.23 | (1.76; 2.84) | 1.71 | (1.32; 2.21) | 1.74 | (1.48; 2.05) | 1.74 | (1.36; 2.22) |
| Long (≥64) | |||||||||||
| Non-users | 455 | 67.6 | 1.2 (1.1; 1.4) | Reference | Reference | Reference | Reference | ||||
| Users | 129 | 36.3 | 1.7 (1.4; 2.0) | 1.47 | (1.21; 1.78) | 1.25 | (1.01; 1.54) | 1.23 | (1.08; 1.40) | 1.24 | (1.01; 1.51) |
| Type of AED | |||||||||||
| Older | 88 | 57.9 | 2.6 (2.1; 3.3) | 1.52 | (1.10; 2.10) | 1.10 | (0.77; 1.57) | 1.46 | (1.03; 2.08) | 1.37 | (1.00; 1.88) |
| Newer | 64 | 42.1 | 1.4 (1.1; 1.9) | Reference | Reference | Reference | Reference | ||||
| Duration of used, f (weeks) | |||||||||||
| Short (<14) | |||||||||||
| Older | 27 | 17.8 | 0.2 (0,4; 1.0) | 1.88 | (1.00; 3.54) | 1.51 | (0.74; 3.05) | 1.27 | (0.83; 1.95) | 1.27 | (0.69; 2.33) |
| Newer | 15 | 9.9 | 0.1 (0.1; 0.4) | Reference | Reference | Reference | Reference | ||||
| Medium (14 to <64) | |||||||||||
| Older | 31 | 20.4 | 0.9 (0.6; 1.3) | 1.60 | (0.92; 2.78) | 1.71 | (0.92; 3.18) | 2.00 | (1.33; 3.01) | 2.00 | (1.12; 3.56) |
| Newer | 21 | 13.8 | 0.4 (0.3; 0.7) | Reference | Reference | Reference | Reference | ||||
| Long (≥64) | |||||||||||
| Older | 30 | 19.7 | 1.2 (0.9; 1.8) | 1.26 | (0.75; 2.10) | 1.20 | (0.69; 2.10) | 1.06 | (0.75; 1.49) | 1.06 | (0.65; 1.72) |
| Newer | 28 | 18.4 | 0.9 (0.6; 1.3) | Reference | Reference | Reference | Reference | ||||
Notes: aAdjusted for age, sex, and time since AD diagnosis (days) by matching. bWeighted with inverse probability of treatment weights (IPTW). cWeighted with stabilized inverse probability of treatment weights (IPTW). dCut-offs based on tertile distribution of duration of AED use: 1st tertile 13.9 weeks, 2nd tertile 63.7 weeks. eReference category for each duration of any AED use group is the non-users with same follow-up duration. fReference category for each duration of older AED use group is the users of newer AEDs with same duration of use.