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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Ann Neurol. 2020 Oct 27;89(1):99–110. doi: 10.1002/ana.25926

Figure 3. Repeated SDs induce lasting periorbital mechanical allodynia.

Figure 3.

Left panel shows individual log force data (grams) from females (triangle) and males (circles) along with the median. Seven SDs once every other day (7SD) reduced periorbital mechanical thresholds 2 and 4 but not 14 days after the last SD compared with sham controls (two-way ANOVA on ranks). Middle panel shows group averages of the same dataset to better illustrate the time course of periorbital allodynia (mean ± SEM). Right panel shows unchanged mechanical hindpaw thresholds in repeated SD and sham groups tested 2 days following the last SD (Mann-Whitney U test).