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. 2021 Apr 26;16(4):e0241728. doi: 10.1371/journal.pone.0241728

Table 1. Name, biological function and pharmaceutical application of best 10 performing targets with PharmaNet.

Target NAP Biological Function Pharmaceutical Application
C-X-C Chemokine Receptor Type 4 (CXCR4) 1 Receptor for the C-X-C chemokine CXCL12/SDF-1 Antiviral
Farnesyl Pyrophosphate Synthase (FPPS) 1 Key enzyme in isoprenoid biosynthesis Antimicrobial and Anticancer
Thymidine Kinase (KITH) 1 Catalyzes the addition of a gamma-phosphate group to thymidine Antimicrobial and Anticancer
Adenosylhomocysteinase (SAHH) 1 Competitive inhibitor of S-adenosyl-L-methionine dependent methyl transferase reaction Anti-inflammatory
Phosphoribosylamine (PUR2) 1 Involved in the synthesizes of N(1)-(5-phospho-D-ribosyl) glycinamide Antimicrobial and Anticancer
Fatty Acid-Binding Protein (FABP4) 1 Lipid transport protein in adipocytes Anti-inflammatory
3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMDH) 1 Transmembrane glycoprotein, rate-limiting enzyme in biosynthesis of cholesterol and nonsterol isoprenoids None
Natural Resistance-Associated Macrophage Protein (NRAM) 1 Divalent transition metal transporter and host resistance to certain pathogens Antibacterial and Immunomodulator
Heat Shock Protein 90-Alpha 1 (HS90A) 1 Involved in cell cycle control and signal transduction Anticancer
Catechol O-Methyltransferase (COMT) 1 Catalyzes the O-methylation—Inactivation of catecholamine neurotransmitters Parkison’s disease