Fig 4. Group differences in median ΔT₁ in non-enhancing white matter lesions.

A: NEL median ΔT₁ comparison for EDSS scores that were > median (3.0) vs. ≤ median. Gadolinium induced greater changes in T₁ in MS participants with higher EDSS scores. B: NEL median ΔT₁ comparison for MS Type, PMS vs. RRMS. Gadolinium induced greater changes in T₁ in participants with PMS. C: NEL median ΔT₁ comparison for multiple sclerosis immunomodulatory treatment, Yes vs. No. Gadolinium induced greater changes in T₁ in participants not on MS treatment. Per subject median ΔT₁ values were used in the Mann-Whitney U-test. NEL = non-enhancing lesion; EDSS = Expanded Disability Status Scale; MS = multiple sclerosis; PMS = progressive multiple sclerosis (PPMS + SPMS); PPMS = primary progressive multiple sclerosis; SPMS = secondary progressive multiple sclerosis; RRMS = relapsing-remitting multiple sclerosis.