Table 1. Demographic and clinical characteristics of the study population.
| Characteristic | Full Cohort (n = 47) |
Relapsing-Remitting MS Subjects (n = 34, 72.3%) |
Progressive MS Subjects (n = 13, 27.7%) |
|---|---|---|---|
| Age, mean (SD) in years | 46.2 (11.2) | 44.3 (11.4) | 51.2 (9.4) |
| Sex, female (%) | 30 (63.8%) | 23 (67.7%) | 7 (53.9%) |
| Symptom duration, mean (SD) in years | 11.5 (8.3) | 11.4 (8.8) | 11.9 (7.2) |
| On MS treatment (%) | 34 (72.3%) | 27 (79.4%) | 7 (53.9%) |
| Interferon-beta | 6 (12.8%) | 4 (11.8%) | 2 (15.4%) |
| Glatiramer acetate | 7 (14.9%) | 7 (20.6%) | 0 (0%) |
| Natalizumab | 4 (8.5%) | 3 (8.8%) | 1 (7.7%) |
| Teriflunomide | 1 (2.1%) | 1 (2.9%) | 0 (0%) |
| Fingolimod | 4 (8.5%) | 3 (8.8%) | 1 (7.7%) |
| Dimethyl Fumarate | 11 (23.4%) | 9 (26.5%) | 2 (15.4%) |
| Rituximab | 1 (2.1%) | 0 (0%) | 1 (7.7%) |
| EDSS score, median (range) | 3.0 (1, 6.5) | 3.0 (1.0, 6.0) | 6.0 (4.0, 6.5) |
| SDMT # correct, mean (SD) | 53.2 (12.3) | 55.7 (12.8) | 46.5 (7.9) |
| PASAT # correct, mean (SD) | 44.8 (12.8) | 45.9 (13.4) | 42.1 (11.3) |
| MFIS score, mean (SD) | 39.5 (20.4) | 35.5 (21.6) | 49.9 (12.3) |
| 9HPTDOM, mean (SD) | 45.3 (111) | 25.3 (15.7) | 40.9 (21.3) |
| 9HPTNONDOM, mean (SD) | 32.3 (22.5) | 27.1 (18.6) | 46.1 (26.6) |
| 25FTW, mean (SD) | 8.66 (13.2) | 5.5 (3.4) | 17.0 (23.2) |
| # of WML, mean (SD) | 87.4 (68.5) | 77.6 (51.8) | 113.1 (98.1) |
| Volume of WML, mean (SD) in mm3 | 6099.8 (5790.4) | 5753.9 (5193.7) | 7004.3 (7288.5) |
| # of cases with enhancing lesions (%) | 5 (10.6%) | 4 (8.5%) | 1 (2.1%) |
| # of enhancing lesions seen in participants with enhancement, median (range) | 1 (1, 3) | 1 (1, 3) | 1 (1, 1) |
SD = standard deviation; # = number; MS = multiple sclerosis; RRMS = relapsing-remitting multiple sclerosis; PMS = progressive multiple sclerosis; EDSS = Expanded Disability Status Scale; SDMT = Symbol Digit Modalities Test; PASAT = Paced Auditory Serial Addition Test; MFIS = Modified Fatigue Impact Scale; 9HPTDOM = 9-hole peg test for dominant hand; 9HPTNONDOM = 9-hole peg test for non-dominant hand; 25FTW = timed 25-foot walk.