Table 3. Correlation of ΔT₁ with WML volume and count.

Tissue	T1 metric (per subject)	WML volume			WML count			WML volume/count
		r	p	adjusted p	r	p	adjusted p	r	p	adjusted p
WML	mean ΔT1	0.194	0.191	0.372	-0.181	0.223	0.372	0.264	0.073	0.230
	variance ΔT1	0.182	0.220	0.372	0.590	< 0.001	< 0.001	-0.150	0.315	0.429
	median ΔT1	0.160	0.284	0.426	-0.272	0.064	0.230	0.261	0.077	0.230
	IQR ΔT1	0.221	0.135	0.338	0.493	< 0.001	0.003	-0.081	0.589	0.680
	kurtosis ΔT1	0.106	0.479	0.599	-0.010	0.949	0.949	0.042	0.777	0.833
NEL	mean ΔT1	0.218	0.140	0.312	-0.175	0.240	0.404	0.273	0.063	0.226
	variance ΔT1	0.139	0.353	0.481	0.582	< 0.001	< 0.001	-0.170	0.254	0.404
	median ΔT1	0.164	0.269	0.404	-0.270	0.066	0.226	0.262	0.075	0.226
	IQR ΔT1	0.216	0.146	0.312	0.489	< 0.001	0.004	-0.082	0.583	0.673
	kurtosis ΔT1	0.005	0.975	0.975	-0.126	0.400	0.500	0.055	0.712	0.763
NAWM	mean ΔT1	0.175	0.240	0.450	0.203	0.172	0.392	0.011	0.941	0.998
	variance ΔT1	0.244	0.099	0.392	0.341	0.019	0.286	0.000	0.998	0.998
	median ΔT1	0.210	0.156	0.392	0.231	0.118	0.392	0.002	0.991	0.998
	IQR ΔT1	0.198	0.183	0.392	0.235	0.111	0.392	0.028	0.851	0.998
	kurtosis ΔT1	-0.154	0.300	0.500	-0.141	0.343	0.514	-0.073	0.626	0.853
cGM	mean ΔT1	0.397	0.006	0.043	0.339	0.020	0.074	0.159	0.287	0.391
	variance ΔT1	0.261	0.076	0.163	0.423	0.003	0.043	-0.069	0.647	0.746
	median ΔT1	0.309	0.035	0.104	0.229	0.122	0.229	0.142	0.340	0.425
	IQR ΔT1	0.263	0.074	0.163	0.356	0.014	0.070	-0.031	0.838	0.838
	kurtosis ΔT1	-0.173	0.244	0.387	-0.168	0.258	0.387	0.047	0.755	0.809

WML = white matter lesion; NEL = non-enhancing lesion; NAWM = normal-appearing white matter; cGM = cortical gray matter.

All p-values are given with actual numbers except values < 0.001. Coefficients with p-values less than 0.05 are shown in bold face. Partial correlations after controlling for age, sex, and symptom duration are provided in S1 Table.