Table 3. ROC curve analysis of individual and combination of sEV-derived miRNAs to differentiate IBC from non-IBC patients.
| EV- derived miRNAs | let-7a-5p | miR-181b-5p | miR-222-3p | miR-222-3p and let-7a-5p panel | let-7a-5p and miR-181b-5p panel | miR-181b-5p and miRNA-222-3p panel |
|---|---|---|---|---|---|---|
| AUC | 0.919 | 0.826 | 0.721 | 0.973 | 0.959 | 0.830 |
| S. E. | 0.036 | 0.059 | 0.069 | 0.018 | 0.029 | 0.058 |
| 95% CI | 0.85–0.99 | 0.71–0.94 | 0.59–0.86 | 0.93–1.00 | 0.90–1.00 | 0.72–0.94 |
| Optimal Cutoff | -2.255 | 0.670 | -0.685 | 0.533 | 0.742 | 0.494 |
| SN (%) | 87.0% | 73.9% | 78.3% | 91.3% | 82.6% | 73.9% |
| SP (%) | 85.3% | 85.3% | 67.6% | 97.1% | 100% | 88.2% |
| PPV (%) | 85.7% | 76.2% | 60.0% | 95.5% | 87.0% | 81.0% |
| NPV (%) | 86.1% | 80.6% | 70.3% | 94.3% | 91.2% | 83.3% |
| p-value | < 0.001 | < 0.001 | < 0.01 | < 0.001 | < 0.001 | < 0.001 |
AUC: area under the curve; CI: confidence interval; SN: sensitivity; SP: specificity; PPV: positive predictive value; and NPV: negative predictive value.