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. 2021 Apr 26;16(4):e0250295. doi: 10.1371/journal.pone.0250295

Table 1. Characteristics of the studies included in this meta-analysis.

Author Year Country Sample size Age (years) Sex (M/F) Treatment TNM stage Types of outcomes Cut-off value Analysis NOS score Follow-up (months) Study type Study period
Liu 2015 China 455 59(19–86) 314/141 Surgery I-III OS 0.25 MV 7 25(1–76) Retrospective 2005–2010
Ni 2016 China 258 NR 184/74 Chemotherapy IV OS 0.5897 MV 6 7(0.2–68) Retrospective 2010–2015
Toiyama 2016 Japan 384 67(32–88) 264/120 Surgery I-III OS, CSS 0.051 MV 8 47.6 Retrospective 2001–2011
Mao 2017 China 337 59(19–89) 237/100 Mixed I-IV OS 0.3778 MV 6 NR Retrospective Jan-Dec, 2010
Saito 2018 Japan 453 NR 331/122 Surgery I-IV OS 0.0232 UV 6 61.9 Retrospective 2005–2013
Toyokawa 2018 Japan 240 64.5 168/72 Surgery II OS 0.03 MV 9 100.5 Retrospective 1997–2012
Liu 2019 China 688 57(21–86) 449/239 Mixed II-III CSS 0.2 MV 8 36(3–162) Retrospective 2000–2012
Lu 2019 China 401 58.6 271/130 Surgery I-III CSS 0.143 MV 9 24(3–35) Prospective 2015–2016

M, male; F, female; NR, not reported; OS, overall survival; CSS, cancer-specific survival; MV, multivariate; UV, univariate; NOS, Newcastle-Ottawa Scale; TNM, tumor node metastasis.