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. 2021 Apr 12;12:642771. doi: 10.3389/fimmu.2021.642771

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Copyright © 2021 Patterson, Byerly and McBride

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Degradation of E. chaffeensis by antibody-TRIM21-mediated selective autophagy. Ehrlichiae opsonized with E. chaffeensis-OMP-1 specific antibody are internalized by unknown uptake mechanism. Intracellular antibody-opsonized ehrlichiae are recognized by cytosolic Fc receptor TRIM21. (1) Induction of TRIMosome formation and selective autophagy occurs through recruitment of autophagy regulators, ULK1, Beclin 1, ATG16L and autophagy effectors LC3/GABARAP and p62/SQSTM1. (2) E. chaffeensis-Ab/TRIM21 complex stimulates rapid immune signaling and a proinflammatory response through accumulation of K48 and K63 polyUb chains and activation and nuclear translocation of NF-κB and IRF.