Table 3.
Comparison of ET Patients with CVST and without CVST
| Variable | ET with CVST (n = 23) | ET without CVST (n = 68) | P value |
|---|---|---|---|
| Gender, female (n, %) | 14 (60.87) | 38 (55.88) | 0.629 |
| Age (years, mean ± SD) | 37.65 ± 14.45 | 60.93 ± 13.46 | <0.001 |
| Age ≥60 y (n, %) | 2 (8.7) | 34 (40.0) | <0.001 |
| Age at ET diagnosis | 37.13 ± 14.11 | 57.73 ± 13.81 | <0.001 |
| Median disease duration, months | 495.96 ± 1137.88 | 914.59 ± 1250.93 | 0.145 |
| Cardiovascular risk factors (n, %) | |||
| Hypertension | 1 (4.34) | 22 (32.35) | 0.003 |
| Diabetes | 0 | 9 (13.24) | 0.063 |
| Dyslipidemia | 1 (4.34) | 7 (10.29) | 0.440 |
| Coronary artery disease | 0 | 10 (14.71) | 0.045 |
| Stroke history | 0 | 9 (13.24) | 0.059 |
| Smoking | 1 (4.34) | 17 (25.00) | 0.035 |
| At least one CVRF | 3 (13.04) | 36 (52.94) | 0.001 |
| Laboratory tests | |||
| Platelet count, ×109/L | 536.17 ± 137.06 | 735.06 ± 264.32 | <0.001 |
| Platelet count >1000×109/L (n, %) | 0 | 11 (16.18) | 0.032 |
| WBC count, ×109/L | 8.86 ± 3.22 | 9.28 ± 3.80 | 0.614 |
| WBC count >11x109/L (n, %) | 5 (21.74) | 12 (17.65) | 0.758 |
| RBC count | 4.39 ± 0.85 | 4.52 ± 0.91 | 0.541 |
| Hemoglobin level (g/dl) | 128.61 ± 26.75 | 134.75 ± 22.92 | 0.290 |
| Hemoglobin level <12g/dl (n, %) | 6 (26.09) | 14 (20.59) | 0.572 |
| HCT | 39.29 ± 7.45 | 40.31 ± 6.91 | 0.549 |
| APTT, sec | 45.03 ± 16.84 | 41.41 ± 3.89 | 0.100 |
| Fibrinogen (g/l) | 2.89 ± 0.94 | 3.01 ± 1.22 | 0.684 |
| D-dimer (0.01–0.5ug/mL) | 0.76 ± 1.29 | 0.47 ± 1.28 | 0.345 |
| JAK2 V617F mutation (n, %) | 21/23 (91.30) | 49 (72.06) | 0.148 |
| Bleeding | 1/22 (4.34) | 5/63 (7.94) | 1.000 |
| Splenomegaly | 10 (43.48) | 29 (42.6) | 0.944 |
| Risk stratification (n, %) | 0.017 | ||
| Low-risk | 0 | 11 (16.18) | - |
| Intermediate-risk | 0 | 8 (11.76) | - |
| High-risk | 23 (100) | 49 (72.06) | - |
| Treatment (n, %) | |||
| Antiplatelet treatment | 17 (73.91) | 65 (95.59) | 0.070 |
| Cytoreductive therapy | 17 (73.91) | 50 (73.53) | 1.000 |
| Hydroxyurea | 14 (60.87) | 36 (52.94) | 0.629 |
| IFN‑α | 6 (26.09) | 25 (36.76) | 0.350 |
Abbreviations: ET, essential thrombocythemia; CVST, cerebral venous sinus thrombosis; SD, standard deviation; CVRF, cardiovascular risk factors; RBC, red blood cell; WBC, white blood cell; HCT, hematocrit; APTT, activated partial thromboplastin time.