. 2020 Jan 14;36(5):862–870. doi: 10.1093/ndt/gfz277

Table 4.

Effect per unit decline in eGFR-MDRD (per year) on annual change in symptom number and severity

	Symptom number (n = 1109)	Symptom severity (n = 1019)
Mean annual increase (95% CI)	0.73 (0.28; 1.19)^*	2.93 (1.34; 4.52)^*
Extra increase per unit^a decline in kidney function
Unadjusted	0.24 (0.08; 0.40)^*	0.88 (0.34; 1.41)^*
Adjusted^b	0.23 (0.07; 0.39)^*	0.87 (0.35; 1.40)^*

One unit is 1 mL/min/1.73 m² decline per year.

Adjusted for: age, sex, ethnicity, country of residence, educational level, diabetes mellitus, cerebrovascular disease, myocardial infarction, hypertension, malignancy, psychiatric disease, BMI, primary kidney disease, haemoglobin and proteinuria at baseline.

P < 0.05.