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. 2020 Jun 26;36(5):871–883. doi: 10.1093/ndt/gfaa158

FIGURE 4.

FIGURE 4

Path analyses showing that SZC significantly increases serum bicarbonate both directly (Path c) and indirectly via reductions in serum urea (Path d × e) at (A) 48 h in the ZS-003 study (n = 736), (B) Day 15 in the HARMONIZE study (n = 208) and (C) Day 15 in the HARMONIZE-Global study (n = 214). Although SZC significantly decreases serum K+ (Path a) and increases urine pH (Path f), the indirect paths via change in serum K+ (Path a × b) and via change in urine pH (Path f × g) were not significant, indicating that SZC-induced changes in serum K+ and urine pH are not responsible for the observed increase in serum bicarbonate with SZC therapy. CFI = 1.000 and RMSEA = 0.000 (P > 0.05) for all models. Path line weights are proportional to the magnitude of the standardized β coefficients.