Table 4.

Path analysis standardized β coefficients

		ZS-003 at 48 h (n = 736)		HARMONIZE at Day 15 (n = 208)		HARMONIZE-Global at Day 15 (n = 214)
Path	Regression	β (95% CI)	P-value	β (95% CI)	P-value	β (95% CI)	P-value
a	Change in serum K+ on treatment	−0.364 (−0.434, −0.294)	<0.001	−0.418 (−0.531, −0.305)	<0.001	−0.444 (−0.543, −0.344)	<0.001
	Change in serum bicarbonate on:
b	Change in serum K+	0.038 (−0.041, 0.118)	0.341	−0.076 (−0.226, 0.073)	0.317	−0.107 (−0.252, 0.038)	0.148
c	Treatment	0.231 (0.161, 0.302)	<0.001	0.234 (0.093, 0.374)	0.001	0.175 (0.012, 0.339)	0.036
e	Change in serum urea	−0.203 (−0.283, −0.123)	<0.001	−0.231 (−0.344, −0.119)	<0.001	−0.215 (−0.364, −0.067)	0.005
g	Change in urine pH	0.063 (−0.022, 0.148)	0.144	0.095 (−0.041, 0.230)	0.172	0.085 (−0.033, 0.202)	0.159
d	Change in serum urea on treatment	−0.131 (−0.197, −0.066)	<0.001	−0.188 (−0.305, −0.071)	0.002	−0.353 (−0.472, −0.233)	<0.001
f	Change in urine pH on treatment	0.133 (0.061, 0.205)	<0.001	0.182 (0.048, 0.316)	0.008	0.238 (0.124, 0.351)	<0.001
a × b	Indirect path via change in serum K+		0.344		0.317		0.150
d × e	Indirect path via change in serum urea		0.003		0.008		0.003
f × g	Indirect path via change in urine pH		0.167		0.219		0.165