Table 1.
Patient | Age (years) | Sex | Ethnicity | MGFA class | Thymectomy | Therapy at eculizumab initiation |
1 | 45 | F | White | IIa | Yes | Prednisone 35 mg/day + pyridostigmine 60 mg TID + IVIg 1g/kg q4w + mycophenolate mofetil 1000 mg BID |
2 | 36 | F | White | IIIa | Yes | Prednisone 30 mg/day + pyridostigmine 60 mg TID + azathioprine 200 mg/day |
3 | 56 | M | White | IIIb | Yes | Prednisone 40 mg/day + mycophenolate mofetil 1000 mg BID + pyridostigmine 60 mg TID |
4 | 72 | M | White | IIa | No | Prednisone 40 mg/day + mycophenolate mofetil 1000 mg BID + pyridostigmine 60 mg TID |
5 | 65 | F | White | IIb | No | IVIg 1g/kg q4w + pyridostigmine 60 mg TID + prednisone 30 mg/day |
6 | 26 | F | White | IIIa | Yes | IVIg 1g/kg q4w + prednisone 40 mg/day + pyridostigmine 60 mg TID |
7 | 66 | M | White | IIb | No | Prednisone 30 mg/day + mycophenolate mofetil 1000 mg BID + pyridostigmine 60 mg TID |
8 | 38 | F | White | IIa | No | Prednisone 40 mg/day + mycophenolate mofetil 1500 mg BID + pyridostigmine 60 mg TID |
9 | 30 | F | White | IIb | Yes | Prednisone 20 mg/day + mycophenolate mofetil 1500 mg BID + pyridostigmine 60 mg TID |
10 | 60 | M | White | IIa | No | Prednisone 40 mg/day + azathioprine 200 mg/day + pyridostigmine 60 mg TID |
11 | 61 | F | Black | IIIb | Yes | IVIg 1g/kg q5w + prednisone 30 mg/day + pyridostigmine 60 mg TID |
12 | 38 | F | White | IIIa | Yes | IVIg 1g/kg q4w + prednisone 20 mg/day + pyridostigmine 60 mg TID |
13 | 24 | F | White | IIIa | Yes | IVIg 1g/kg q4w + prednisone 45 mg/day + pyridostigmine 60 mg TID + mycophenolate mofetil 1000 mg BID |
14 | 43 | M | White | IIb | Yes | Prednisone 40 mg/day + pyridostigmine (dose unknown) |
15 | 51 | M | White | IIa | No | Prednisone 40 mg/day + pyridostigmine 60 mg TID + mycophenolate mofetil 1000 mg BID |
BID, twice daily; F, female; IVIg, intravenous immunoglobulin; M, male; MGFA, Myasthenia Gravis Foundation of America; qnw, every n weeks; TID, three times daily.