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. 2021 Mar 23;80(2):877–883. doi: 10.3233/JAD-201451

Table 4.

Associations between the initial ratio or the ratio changes in PVH/DWMH volumes to ICV, and changes in neuropsychological test scores and blood biochemistry data

Initial PVH vol. ratio Changes in PVH vol. ratio Initial DWMH vol. ratio Changes in DWMH vol. ratio
Changes in measurement Coefficient P Coefficient P Coefficient P Coefficient P
MMSE –0.32 0.13 –0.2 0.35 –0.15 0.5 –0.5* 0.01
FAB 0.27 0.21 0.003 0.99 –0.02 0.93 0.11 0.62
TMT-A 0.07 0.76 0.25 0.26 –0.08 0.73 0.08 0.74
TMT- B 0.18 0.43 –0.04 0.85 0.5* 0.02 0.33 0.14
WMS-R 0.35 0.1 0.41 0.05 0.2 0.37 0.29 0.17
VF –0.35 0.12 –0.43 0.05 –0.21 0.36 –0.46* 0.04
GDS-15 –0.11 0.61 –0.28 0.2 0.4 0.06 0.02 0.93
Cystatin C –0.14 0.51 –0.25 0.25 0.55** 0.005 0.18 0.41

*p < 0.05, significant correlation with the initial ratio or ratio changes of DWMH volume to ICV. **p < 0.01, significant correlation with the initial ratio of DWMH volume to ICV. MMSE, Mini-Mental State Examination; FAB, Frontal Assessment Battery; TMT, Trail Making Test; WMS-R, Wechsler Memory Scale-Revised; VF, verbal fluency; GDS, Geriatric Depression Scale; PVH, periventricular hyperintensities; DWMH, deep white matter hyperintensities; ICV, intracranial volume.