Table 3.
Regions of significant elevated 11C-PK11195 BP in patients with AD compared to HC
| Region | Cluster size | MNI coordinates | T value | Cohen’s d | ||
| X | Y | Z | ||||
| Parahippocampal gyrus (BA36) | 216 | –16 | 2 | –36 | 5.03 | 1.73 |
| –32 | 10 | –40 | 3.03 | 1.04 | ||
| Isthmus of cingulate gyrus (BA31) | 3059 | –2 | –46 | 52 | 4.94 | 1.70 |
| –10 | –42 | 42 | 4.88 | 1.67 | ||
| –30 | –55 | 38 | 4.02 | 0.61 | ||
| Isthmus of cingulate gyrus (BA31) | 267 | 16 | –62 | 28 | 4.47 | 1.53 |
| Posterior cingulate cortex (BA23) | 126 | 8 | –44 | 30 | 4.06 | 1.39 |
| Superior frontal gyrus (BA6) | 183 | 12 | –8 | 70 | 4.00 | 1.37 |
| 12 | –26 | 70 | 2.95 | 1.01 | ||
| Superior frontal gyrus (BA8) | 253 | 18 | 36 | 46 | 3.94 | 1.35 |
| 8 | 42 | 46 | 3.20 | 1.10 | ||
| 8 | 32 | 52 | 3.17 | 1.09 | ||
| Dorsal anterior cingulate (BA32) | 393 | –8 | 8 | 44 | 3.79 | 1.30 |
| –25 | 18 | 42 | 3.57 | 1.19 | ||
| –4 | 0 | 74 | 3.12 | 1.07 | ||
| Inferior frontal lobe (BA44) | 162 | 52 | 20 | 20 | 3.48 | 1.19 |
| 56 | 10 | 20 | 3.42 | 1.17 | ||
| 40 | 20 | 22 | 2.80 | 0.96 | ||
| Parahippocampal gyrus (BA36) | 136 | 16 | –10 | –34 | 3.35 | 1.15 |
| Lateral temporal lobe (BA21) | 161 | –54 | –34 | –8 | 3.33 | 1.14 |
| –60 | –38 | –16 | 3.26 | 1.12 | ||
| Middle frontal gyrus (BA6) | 119 | 24 | 14 | 46 | 3.26 | 1.12 |
| 22 | 10 | 62 | 2.83 | 0.97 | ||
| 32 | 6 | 60 | 2.69 | 0.92 | ||
BA, Broadman areas; clusters were considered significant using a voxel-wise statistical threshold of p < 0.01 (uncorrected) with an extent threshold of 100 voxels.