Table 4.
Results from ANCOVA reflecting regions where VBM-GM differences were not explained by 11C-PiB SUVR levels in AD
| Region | Cluster size | MNI coordinates | T value | Cohen’s d | ||
| X | Y | Z | ||||
| Amygdala/Parahippocampal gyrus (BA36) | 3594 | –21 | 9 | –27 | 7.76 | 2.70 |
| –38 | –33 | –17 | 6.13 | 2.13 | ||
| –24 | 15 | –23 | 5.93 | 2.06 | ||
| Thalamus | 2697 | –5 | –15 | 8 | 6.87 | 2.39 |
| 12 | –15 | 12 | 5.65 | 1.97 | ||
| –5 | 3 | –2 | 5.50 | 1.91 | ||
| Hippocampus | 1380 | 38 | –17 | –21 | 5.95 | 2.07 |
| 39 | –26 | –17 | 5.52 | 1.92 | ||
| 21 | –9 | –17 | 5.37 | 1.87 | ||
| Frontal lobe (BA47) | 297 | 33 | 48 | –9 | 5.59 | 1.95 |
| 36 | 39 | –14 | 4.81 | 1.68 | ||
| 27 | 38 | –15 | 3.67 | 1.28 | ||
| Prefrontal cortex (BA10) | 1025 | 29 | 60 | 8 | 5.51 | 1.92 |
| 14 | 68 | 5 | 5.19 | 1.81 | ||
| 23 | 62 | 14 | 5.03 | 1.75 | ||
| Fusiform gyrus (BA37) | 71 | –50 | –51 | –27 | 5.33 | 1.86 |
| Prefrontal cortex (BA10) | 120 | –44 | 50 | 17 | 5.24 | 1.82 |
| Prefrontal cortex (BA10) | 163 | –30 | 62 | 0 | 4.94 | 1.72 |
| –33 | 60 | 8 | 4.51 | 1.57 | ||
| Superior parietal cortex (BA7) | 185 | 0 | –63 | 51 | 4.80 | 1.67 |
| –3 | –65 | 60 | 3.60 | 1.25 | ||
| Prefrontal cortex (BA11) | 165 | –18 | 29 | –20 | 4.79 | 1.67 |
| Superior parietal cortex (BA7) | 90 | –3 | –77 | 41 | 4.72 | 1.64 |
| Superior parietal cortex (BA7) | 95 | 35 | –44 | 51 | 4.49 | 1.56 |
| Visual associative cortex (BA18) | 139 | 14 | –41 | 0 | 4.43 | 1.54 |
| Prefrontal cortex (BA11) | 135 | 17 | 20 | –23 | 4.41 | 1.53 |
| 17 | 30 | –18 | 3.46 | 1.20 | ||
| Parietal cortex (BA40) | 63 | –45 | –48 | 57 | 4.35 | 1.51 |
| Superior temporal gyrus (BA22) | 111 | 51 | 6 | –2 | 4.31 | 1.50 |
| 50 | 14 | –6 | 4.04 | 1.41 | ||
| 54 | 14 | 3 | 3.71 | 1.29 | ||
| Frontal cortex (BA6) | 710 | –3 | 21 | 62 | 4.31 | 1.50 |
BA, Broadman areas; clusters were considered significant using a voxel-wise statistical threshold of p < 0.03 (FDR corrected for multiple comparisons) with an extent threshold of 60 voxels.