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. 2021 Apr 12;12:586788. doi: 10.3389/fphar.2021.586788

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Copyright © 2021 Zhou, Liu, Liu, Ma, Zhao, Jiang, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Xiaoyaosan elevates the expression of PI3K in the hippocampal CA1 region of CUMS rats (A) Representative micrographs of immunohistochemical staining (sections were counterstained with hematoxylin; original magnification, ×200) and (B) quantitative analysis showing the expression of PI3K in the hippocampal CA1 region (C) Level of PI3K mRNA in the hippocampal CA1 region (D) Representative images and western blot analysis (E) of western blot assay showing the relative expression of PI3K in the hippocampal CA1 region. All data are expressed as the mean ± SD. #p < 0.05 compared to the control group; *p < 0.05, compared to the vehicle (W) group; ▲p < 0.05 compared to the Ly294002 group; ^& p < 0.05 compared to the Xiaoyaosan group, n = 6.