Table 1.
Characteristics of clusters by age group
| Critically Ill Children Cohort 1 | ||||
| Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | |
| Total, No. (%) | 2,162 (68) | 583 (18) | 203 (6) | 232 (7) |
| Max. pSOFA subscores, median (IQR) | ||||
| Respiratory | 3 (3-4) | 0 (0-0) | 0 (0-0) | 0 (0-0) |
| Coagulation | 0 (0-1) | 3 (2-4) | 1 (0-2) | 0 (0-0) |
| Hepatic | 0 (0-0) | 0 (0-2) | 0 (0-0) | 0 (0-2) |
| Cardiovascular | 1 (1-2) | 1 (1-3) | 1 (1-2) | 2 (1-3) |
| Neurologic | 3 (2-3) | 2 (1-2) | 2 (1-2) | 3 (2-3) |
| Renal | 0 (0-0) | 0 (0-0) | 4 (3-4) | 0 (0-0) |
| Critically Ill Children Cohort 2 | ||||
| Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | |
| Total, No. (%) | 1,811 (86) | 113 (5) | 133 (6) | 60 (3) |
| Max. pSOFA subscores, median (IQR) | ||||
| Respiratory | 3 (2-4) | 0 (0-0) | 0 (0-0) | 0 (0-0) |
| Coagulation | 0 (0-1) | 3 (2-3) | 0 (0-2) | 0 (0-0) |
| Hepatic | 0 (0-0) | 2 (0-2) | 0 (0-0) | 2 (2-3) |
| Cardiovascular | 1 (1-1) | 1 (1-3) | 1 (0-1) | 1 (1-1) |
| Neurologic | 4 (3-4) | 0 (0-1) | 1 (0-2) | 2 (1-4) |
| Renal | 0 (0-0) | 0 (0-0) | 3 (2-4) | 1 (0-2) |
| Critically Ill Young and Middle-Aged Adult Cohort | ||||
| Cluster 1 | Cluster 2 | Cluster 3 | - | |
| Total, No. (%) | 4,635 (87) | 361 (7) | 324 (6) | - |
| Max. SOFA subscores, median (IQR) | ||||
| Respiratory | 3 (2-3) | 0 (0-0) | 0 (0-0) | - |
| Coagulation | 1 (0-2) | 2 (2-3) | 2 (0-2) | - |
| Hepatic | 0 (0-1) | 2 (2-3) | 0 (0-2) | - |
| Cardiovascular | 1 (1-3) | 1 (1-3) | 1 (1-2) | - |
| Neurologic | 4 (3-4) | 0 (0-1) | 0 (0-1) | - |
| Renal | 0 (0-1) | 0 (0-1) | 4 (2-4) | - |
Abbreviations: SOFA, Sequential Organ Failure Assessment; pSOFA, pediatric Sequential Organ Failure Assessment; IQR, interquartile range.