Table 2.
Characteristics of the three phenotypes by age group
| Severe Hypoxemia and Shock Phenotype | Thrombocytopenia and Shock Phenotype | Renal Dysfunction and Shock Phenotype | ||||
| Pediatric | Adult | Pediatric | Adult | Pediatric | Adult | |
| Total, No. (%) | 2,335 (44) | 2,157 (41) | 536 (10) | 330 (6) | 131 (2) | 274 (5) |
| Male, No. (%) | 1,310 (56) | 1396 (64.7) | 301 (56) | 200 (60.6) | 92 (70) | 163 (59.5) |
| Age in years, median (IQR) | 2.5 (0.6-9.9) | 46.2 (38.2-51.2) | 11.3 (3.6-16.1) | 47.2 (40.4-51.3) | 10.3 (2.5-15.8) | 46.9 (39.3-50.7) |
| Race/ethnicity, No. (%) | ||||||
| White Non-Hispanic | 695 (29.8) | 1414 (65.6) | 215 (40.1) | 242 (73.3) | 43 (32.8) | 138 (50.4) |
| Black Non-Hispanic | 892 (38.2) | 188 (8.7) | 70 (13.1) | 19 (5.8) | 46 (35.1) | 94 (34.3) |
| Hispanic | 520 (22.3) | 125 (5.8) | 194 (36.2) | 16 (4.9) | 31 (23.6) | 21 (7.6) |
| Other | 228 (9.8) | 430 (20) | 57 (10.6) | 53 (16) | 11 (8.4) | 21 (7.7) |
| Comorbidity, No. (%) | ||||||
| Chronic Cardiovascular | 652 (27.9) | 853 (39.6) | 183 (34.1) | 95 (28.8) | 47 (35.9) | 144 (52.6) |
| Chronic Respiratory | 502 (21.5) | 390 (18.1) | 54 (10.1) | 33 (10) | 11 (8.4) | 37 (13.5) |
| Chronic Renal | 73 (3.1) | 179 (8.3) | 20 (3.7) | 45 (13.6) | 131 (100) | 213 (77.7) |
| Cancer | 182 (7.8) | 106 (4.9) | 246 (45.9) | 47 (14.2) | 12 (9.2) | 8 (2.9) |
| Multiple Comorbidities | 1,296 (55.5) | 523 (24.3) | 383 (71.5) | 114 (34.6) | 108 (82.4) | 165 (60.2) |
| Infection, No. (%) | 1,303 (55.8) | 1102 (51.1) | 383 (71.5) | 222 (67.3) | 65 (50) | 134 (48.9) |
| Max. SOFA/pSOFA subscores in the first 72h, median (IQR) | ||||||
| Respiratory | 3 (3-4) | 3 (3-4) | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-1) |
| Coagulation | 0 (0-0) | 1 (0-2) | 3 (3-3) | 3 (3-3) | 0 (0-0) | 0 (0-2) |
| Hepatic | 0 (0-0) | 0 (0-1) | 0 (0-1) | 2 (1-3) | 0 (0-0) | 0 (0-0) |
| Cardiovascular | 1 (1-3) | 1 (1-4) | 1 (1-3) | 1 (1-1) | 1 (1-2) | 1 (1-3) |
| Neurologic | 3 (3-4) | 4 (3-4) | 1 (0-2) | 2 (1-3) | 1 (0-2) | 2 (1-3) |
| Renal | 0 (0-1) | 0 (0-1) | 1 (0-2) | 1 (0-2) | 4 (4-4) | 4 (4-4) |
| Laboratory test results in the first 72h, median (IQR) | ||||||
| Max. WBC, K/uL | 13.5 (9.4-18.9) | 15.9 (11.4-21.3) | 5.9 (0.9-12.9) | 8.3 (4.7-13.3) | 13.2 (9.8-18.1) | 13.5 (9.5-18.3) |
| Min. Lymphocytes, K/ | uL 1.2 (0.6-2) | 1 (0.5-1.6) | 0.3 (0.1-0.8) | 0.6 (0.3-1) | 0.9 (0.5-1.9) | 1 (0.5-1.3) |
| Min. Hemoglobin, g/d | L 8.8 (7.3-10.4) | 9.2 (8-10.8) | 7.5 (6.5-8.7) | 8.2 (7.1-9.2) | 8.3 (7.5-9.9) | 8.9 (8-10.2) |
| Max. INR | 1.4 (1.2-1.9) | 1.4 (1.2-1.9) | 1.5 (1.2-2) | 1.8 (1.4-2.5) | 1.2 (1-1.3) | 1.5 (1.2-2.1) |
| Max. PTT, sec. | 39 (32-53) | 36 (29-57) | 41 (32-57) | 42 (33-57) | 27 (32-44) | 36 (31-57) |
| Max. BUN, mg/dL | 13 (9-20) | 21 (14-34) | 15 (10-24) | 29 (17-54) | 59 (46-78) | 65 (47-86) |
| Max. ALT, U/L | 31 (17-95) | 46 (25-120) | 46 (23-114) | 53 (29-99) | 28 (15-148) | 40 (22-92) |
| Max. Lactate, mmol/L | 2.2 (1.3-4.5) | 3.1 (1.9-5.5) | 2 (1.2-3.6) | 3.1 (1.9-5.2) | 1.5 (1.1-2.8) | 2.2 (1.5-3.3) |
| Hospital LOS in days, median (IQR) | 13 (6-24) | 13 (7-23) | 10 (5-18) | 10 (6-22) | 10 (7-17) | 9 (6-16) |
| In-hospital mortality, No. (%) | 315 (13.5) | 443 (20.5) | 56 (10.4) | 87 (26.4) | 3 (2.3) | 32 (11.7) |
| MODS on day7, No. (%) | 1,025 (44) | 1,144 (53) | 139 (25.9) | 67 (20.3) | 19 (10.2) | 45 (16.4) |
Abbreviations: SOFA, Sequential Organ Failure Assessment; pSOFA, pediatric Sequential Organ Failure Assessment; IQR, interquartile range; WBC, White blood cells; INR, International Normalized Ratio; PTT, partial thromboplastin time; BUN, blood urea nitrogen; ALT, Alanine aminotransferase; LOS, length of stay; MODS, multiple organ dysfunction syndrome.