Table 3.

Eligibility criteria of a hypothetical trial constructed based on NCT00478205.

Num	Short Name	Inclusion/ Exclusion	Criteria Definitions
1	Age	Inclusion	age at first donepezil date 45 - 90
2	Donepezil days	Inclusion	days on donepezil >= 90 days
3	Visual/hearing Impairment	Exclusion	patients with visual impairment or hearing impairment*
4	Cardiac diseases	Exclusion	patients with acute myocardial infraction, atrial fibrillation, heart failure, or ischemic heart disease*
5	Uncontrolled Hypertension	Exclusion	patients with hypertension and have systolic blood pressure > 140 or diastolic blood pressure > 90 in recent 3 months*
6	Uncontrolled diabetes	Exclusion	patients with diabetes and have HbA1c > 7 % in recent 3 months*
7	Other AD treatments	Exclusion	patients taken any of Tacrine, Pyridostigmine, Galantamine, Isoflurophate, Demecarium, Physostigmine, Rivastigmine, Edrophonium, or Ambenonium
8	Dementias other than AD	Exclusion	patients had no diagnosis of AD but had diagnosis of other dementias
9	Parkinsons disease	Exclusion	patients diagnosed with Parkinsons disease
10	Schizophrenia	Exclusion	patients with schizophrenia*
11	Depression	Exclusion	patients with depression*
12	Sleep disorder	Exclusion	patients diagnosed with sleep disorder
13	Drug use disorders	Exclusion	patients with drug use disorders*
14	Alcohol use disorders	Exclusion	patients with alcohol use disorders*
15	Conditions affect absorption, distribution, or metabolism of the study medication	Exclusion	patients diagnosed with any of inflammatory bowel disease, gastric or duodenal ulcers, or hepatic disease
16	Cancer	Exclusion	patients with a history of cancer (does not include basal or squamous cell carcinoma of the skin, benign prostatic hyperplasia) within 5 years*
17	Use antidepressants	Exclusion	patients prescribed with any of amitriptyline, clomipramine, doxepin, imipramine, trimipramine, protriptyline, amoxapine, desipramine, or nortriptyline
18	Fecal/urinary incontinence	Exclusion	patients diagnosed with fecal or urinary incontinence

^*These criteria were constructed based on CMS CCW chronic condition algorithms.