Table 2. Predictors of hospital mortality on multivariable elastic net regression.
Only predictors with p <0.1 are shown. Additional predictors included in the model were female gender, white race, BMI, APACHE-III score, prior stroke, prior HF, prior stroke, prior CKD, prior diabetes, prior liver disease, prior lung disease, prior dialysis invasive ventilator, noninvasive ventilator, RBC transfusion, PAC, IABP, coronary angiography, CRRT, number of vasoactive drugs, admission diagnosis of sepsis, admission diagnosis of VT/VF, admission diagnosis of ACS, admission systolic BP, admission HR, admission oxygen saturation, admission respiratory rate, admission MAP, admission GCS, admission hemoglobin, admission sodium, admission potassium, admission bicarbonate. Candidate variables not included in the model were prior cancer, admission diastolic BP, admission WBC count, admission diagnosis of CS, and admission diagnosis of HF. Final model AUC = 0.937.
| Variable | Adjusted OR | 95% CI | P value |
|---|---|---|---|
| Age (per year) | 1.027 | 1.017–1.038 | <0.001 |
| Mean week 1 SOFA score | 1.454 | 1.373–1.539 | <0.001 |
| Charlson Comorbidity Index | 1.078 | 1.016–1.142 | 0.01 |
| PCI | 0.724 | 0.541–0.969 | 0.03 |
| Dialysis | 2.184 | 1.307–3.649 | 0.003 |
| Admission diagnoses | |||
| Cardiac arrest | 4.651 | 3.426–6.313 | <0.001 |
| Shock | 1.678 | 1.198–2.351 | 0.003 |
| Respiratory failure | 1.407 | 1.033–1.918 | 0.03 |
| SVT/AF | 0.738 | 0.574–0.950 | 0.02 |
| Admission laboratory data | |||
| Chloride (per mEq/L) | 0.954 | 0.926–0.982 | 0.002 |
| BUN (per mg/dL) | 1.011 | 1.04–1.017 | <0.001 |
| Creatinine (per mg/dL) | 0.868 | 0.764–0.985 | 0.03 |
| Neutrophils (per 103 per mm3) | 1.032 | 1.010–1.055 | 0.005 |
ACS = acute coronary syndrome; AF = atrial fibrillation; AKI = acute kidney injury; APACHE = Acute Physiology and Chronic Health Evaluation; BMI = body mass index; BP = blood pressure; BUN = blood urea nitrogen; CICU = cardiac intensive care unit; CKD = chronic kidney disease; CRRT = continuous renal replacement therapy; CS = cardiogenic shock; GCS = glasgow coma scale; HF = heart failure; HR = heart rate; IABP = intra-aortic balloon pump; LOS = length of stay; MAP = mean arterial pressure; PAC = pulmonary arterial catheter; PCI = percutaneous intervention; RBC = red blood cell; SOFA = sequential organ failure assessment; SVT = supraventricular tachycardia; VF = ventricular fibrillation; VT = ventricular tachycardia; WBC = white blood cell.