Table 2.
Association between validated SNPs and DKD-related traits in study participants.
| SNP | Chr | Gene | Position (building 37) | Minor/major allele | Traits | Stage 1 (n = 575) | Stage 2 (n = 2678) | Meta-analysis | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | SE | P value | β | SE | P value | β | SE | P value | ||||||
| rs3116494 | 2 | CD28 | 204592021 | G/A | Creatinine | 3.34 | 2.47 | 0.1763 | 5.59 | 3.54 | 0.1143 | 4.08 | 2.03 | 0.0442 |
| eGFR | -3.27 | 1.89 | 0.0836 | -3.91 | 2.41 | 0.1047 | -3.51 | 1.49 | 0.0181 | |||||
| uAER | 10.86 | 7.34 | 0.1390 | 2.75 | 2.08 | 0.1861 | 3.35 | 2.00 | 0.0939 | |||||
|
| ||||||||||||||
| rs3850890 | 3 | CD80 | 119265619 | C/T | Creatinine | 2.16 | 1.68 | 0.1985 | 1.88 | 1.96 | 0.3375 | 2.04 | 1.28 | 0.1095 |
| eGFR | -2.37 | 1.57 | 0.1312 | -2.97 | 1.34 | 0.0267 | -2.72 | 1.02 | 0.0077 | |||||
| uAER | 19.94 | 11.16 | 0.0740 | 2.61 | 1.19 | 0.0283 | 2.80 | 1.18 | 0.0178 | |||||
P values were calculated by multiple linear regression under an additive genetic model adjusted for age, gender, body mass index, duration of diabetes, and HbA1c; the effect values were evaluated by minor allele. P < 0.05 was considered statistically significant. Chr: chromosome; eGFR: estimated glomerular filtration rate; uAER: urinary albumin excretion rate.