Table 2.
Univariate Cox hazard analysis of risk factors for PFS and OS.
| Variables | PFS | OS | ||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| Sex | ||||
| Male | ||||
| Female | 0.702 (0.295–1.672) | 0.413 | 0.437 (0.094–2.025) | 0.29 |
| Age | ||||
| ≤40 years | ||||
| >40 years | 0.653 (0.284–1.502) | 0.315 | 3.254 (0.946–11.193) | 0.061 |
| Type of lymphoma | ||||
| HL | 0.156 | 0.668 | ||
| B | 0.492 (0.175–1.385) | 0.179 | 2.503 (0.308–20.358) | 0.391 |
| T | 1.132 (0.418–3.065) | 0.807 | 1.858 (0.193–17.882) | 0.592 |
| Ann Arbor stage | ||||
| I-II | ||||
| III-IV | 1.366 (0.514–3.631) | 0.532 | 31.09 (0.086–11310.060) | 0.253 |
| Extranodal lesions | ||||
| <2 | ||||
| ≥2 | 1.116(0.496–2.509) | 0.791 | 1.448 (0.442–4.747) | 0.541 |
| LDH | ||||
| ≤ULN | ||||
| >ULN | 1.662 (0.698–3.961) | 0.251 | 1.662 (0.440–6.285) | 0.454 |
| ECOG PS | ||||
| <2 | ||||
| ≥2 | 1.640 (0.221–12.166) | 0.628 | 6.050 (0.725–50.467) | 0.096 |
| Conditioning regimen | ||||
| BEAM | 0.344 | 0.818 | ||
| BuCy | 0.606 (0.141–2.611) | 0.502 | 1.145 (0.136–9.665) | 0.901 |
| Others | 1.820 (0.679–4.883) | 0.234 | 1.654 (0.349–7.845) | 0.526 |
| Number of previous treatments | ||||
| 1 | ||||
| ≥2 | 1.827 (0.825–4.046) | 0.137 | 4.981 (1.075–23.084) | 0.04∗ |
| Status at SCT | ||||
| CR + PR | ||||
| SD + PD | 1.235 (0.492–3.097) | 0.653 | 0.950 (0.204–4.415) | 0.948 |
| Post-auto-SCT FDG PET-CT | ||||
| Negative (DS < 4) | ||||
| Positive (DS = 4 or 5) | 3.432 (1.585–7.526) | 0.002∗ | 4.078 (1.161–14.320) | 0.028∗ |
∗ p < 0.05.