Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Main pharmacokinetic parameters of 10-hydroxy mesaconitine in rats.
| Parameters | Unit | iv 0.1 mg/kg | po 5 mg/kg |
|---|---|---|---|
| AUC(0 − t) | ng/mL·h | 23.6 ± 5.9 | 207.6 ± 72.9 |
| AUC(0 − ∞) | ng/mL·h | 23.7 ± 5.9 | 208.9 ± 73.1 |
| T 1/2z | h | 1.3 ± 0.6 | 3.1 ± 0.4 |
| V z | L/kg | 0.083 | |
| CLz | L/h/kg | 8.1 ± 4.4 | |
| V z/F | L/kg | 2.8 ± 1.8 | |
| CLz/F | L/h/kg | 117.9 ± 47.3 | |
| C max | ng/mL | 4.4 ± 1.0 | 26.3 ± 8.6 |
| Bioavailability | 17.6% |
