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. 2021 Apr 19;2021:6680192. doi: 10.1155/2021/6680192

Figure 3.

Figure 3

Intraperitoneal injection of XAV939 attenuated mechanical allodynia and decreased TNF-α and IL-18 levels in serum after CCD. (a) Schematic time course for acclimation, CCD surgery, intraperitoneal injection of XAV939, behavioral testing, and sacrifice. (b) MWT measured on 0, 1, 3, 5, and 7 days after CCD treatment (n = 9). Two-way ANOVA. Western blot showing active β-catenin expression in (c) DRG and (d) SCDH (n = 6). ELISA showing the expression of (e) TNF-α and (f) IL-18 in the serum of rats after intraperitoneal injection of XAV939 (n = 6). Serum was collected at different time points after CCD. One-way ANOVA. Bars represent group means ± SD. ####P < 0.0001, CCD+vehicle versus sham; ∗∗∗∗P < 0.0001, CCD+XAV939 versus CCD+vehicle.