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(a) Area (mm2) and (b) rate of wound contraction (%) in rats treated with doxycycline hyclate (Dx) after 7, 14, and 21 days of treatment. Dx1: doxycycline hyclate (10 mg/kg), Dx2: doxycycline hyclate (30 mg/kg). The data are expressed as mean and standard deviation. Statistical difference (Kruskal–Wallis test, p < 0.05) compared to the ∗control group.
