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. 2021 Mar 26;14(3):605–614. doi: 10.1038/s41385-021-00382-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative flow cytometric plots of CD8⁺ T cells and CD8⁺ T cell differentiation in fetal (F; blue), infant (I; purple), and adult (A; gray) intestinal tissues. b Frequencies (%) of CD3⁺ CD8⁺ cells. c The absolute cell counts per cm² of CD8⁺ T cells. d Frequencies (%) of CD8⁺ T cell subsets determined by CCR7 versus CD45RA. e Representative histograms of CD27 and CD28-expression by CD8⁺ Tem cells and the frequencies (%) of CD27 and CD28 on CD8⁺ Tem cells. Error bars represent median percentage ± IQR. The figure represents intestinal epithelium (b, d, e: fetal n = 7, infant n = 9, adult n = 5; c: fetal n = 5, infant n = 6, adult n = 5) and lamina propria (b, d, e: fetal n = 9, infant n = 9, adult n = 10; c: fetal n = 8, infant n = 8, adult n = 6) tissues. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, all Mann–Whitney U analyses.