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. 2021 Mar 26;14(3):605–614. doi: 10.1038/s41385-021-00382-x

Fig. 6. Infant intestinal CD127− CD8+ T early effector cells show increased PD-1-expression.

Fig. 6

a Representative flow cytometric plots of PD-1-expression by total and CD127− CD8+ T cells (Tn cells excluded) at steady state (−) and after stimulation with anti-CD3 and anti-CD28 (anti-CD3/28) + IL-2 + IL-15 (+) in fetal (F; blue), infant (I; purple), and adult (A; gray) intestinal tissues. b Frequencies (%) of PD-1+ within total CD8+ T cells (Tn cells excluded) with and without stimulation. c Frequencies (%) of PD-1+ CD127− CD8+ T cells (Tn cells excluded) with and without stimulation. Error bars represent median percentage ± IQR. This figure represents intestinal lamina propria (−: fetal n = 7, infant n = 8, adult n = 7; +: fetal n = 3, infant n = 3, adult n = 3) tissues. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0,0001, all Two-way ANOVA’s with Bonferroni’s correction.