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. 2021 Mar 5;14(3):667–678. doi: 10.1038/s41385-021-00375-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a In situ zymography of elastolytic activity in colonic mucosal biopsies from control groups (healthy) and inflammatory bowel disease (IBD) patients taken in non-inflamed and inflamed areas. Images colouring correspond to the intensity of fluorescence released after the proteolytic cleavage of elastine substrate according to the reported scale. Representative images of healthy controls tissue section (n = 15), non-inflammatory (NI-IBD) (n = 9), and inflammatory (I-IBD) areas from IBD patients (n = 15). Medians are represented. ***p < 0.001 compared to healthy patients using two-way ANOVA with Bonferroni post-test. Scale bar = 20 μm. b In situ zymography of elastolytic activity in colonic mucosal biopsies in presence or not of 100 nM of ELAFIN, an elastase inhibitor, added exogenously to the tissue slices. These pictures are representative images generated in five patients suffering from CD and UC and healthy control patients. DAPI staining showing nuclei is also represented for each section. Scale bar = 50 μm.