Table 2.
Functional parameters measured at the end of animal experiment
| Parameters | SC (n = 4) | UC (n = 4) | ET (n = 5) |
|---|---|---|---|
| Body weight (g) | 396 ± 6 | 409 ± 6 | 351 ± 11*# |
| Urine output (mL/d/100 g BW) | 19.2 ± 0.6 | 23.0 ± 1.4* | 42.0 ± 2.1*# |
| Plasma sodium (mmol/L) | 146 ± 2 | 148 ± 2 | 148 ± 1 |
| Plasma creatinine (mg/dL) | 0.46 ± 0.05 | 0.52 ± 0.04 | 0.43 ± 0.05 |
| Urine sodium excretion (mmol/d/100 g BW) | 7.75 ± 0.88 | 7.24 ± 0.62 | 8.85 ± 1.46 |
| Fractional excretion of sodium (%) | 7.1 ± 0.8 | 6.7 ± 0.4 | 4.9 ± 0.2 |
| Urine creatinine excretion (mg/d/100 g BW) | 3.4 ± 0.2 | 3.8 ± 0.1 | 4.7 ± 0.3*# |
| Proteinuria (mg/d/100 g BW) | 3.9 ± 0.5 | 4.2 ± 0.3 | 8.8 ± 0.3*# |
| Albuminuria (mg/d/100 g BW) | 0.04 ± 0.01 | 0.23 ± 0.19 | 0.14 ± 0.05 |
| Urine glucose excretion (mg/d/100 g BW) | 0.5 ± 0.0 | 0.5 ± 0.0 | 470.2 ± 53.1*# |
| Urine osmoles (mosmoles/d/100 g BW) | 20.6 ± 1.2 | 19.3 ± 0.7* | 29.8 ± 1.8*# |
| Creatinine clearance (mL/min/100 g BW) | 0.53 ± 0.05 | 0.51 ± 0.04 | 0.84 ± 0.04*# |
| Urine KIM-1/creatinine ratio (mg/μg) | 2.79 ± 0.53 | 4.15 ± 1.44 | 1.49 ± 0.28*# |
Values are presented as mean ± SE
SC sham controls, UC uninephrectomized controls, ET empagliflozin-treated rats
*P < 0.05, versus SC; #P < 0.05, versus UC