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. 2019 Jun 13;34(1):100–114. doi: 10.1038/s41375-019-0507-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — ND2158 impacts on the tumor microenvironment in the TCL1 adoptive transfer model. a Left panel: Absolute counts of monocytes in the spleen (SP) of vehicle- (n = 7) and ND2158-treated (n = 7) mice. Right panel: CCR2 protein expression (MFI) on Ly6C⁺ monocytes in the spleen acquired by flow cytometry. b Left panel: Absolute numbers of CD8⁺ effector and memory T cells in the spleen acquired by flow cytometry. Right panel: Percentage of Ki-67⁺CD8⁺ effector and memory T cells in the spleen of vehicle- and ND2158-treated mice analyzed by flow cytometry. c Protein expression analysis of inhibitory receptors and activation markers on CD8⁺ effector T cells by flow cytometry. Data are shown as percentage of TIGIT⁺, CD160⁺, CD244⁺, LAG3⁺, and CXCR3⁺ CD8⁺ effector T cells for bimodal populations or as MFI of costimulatory receptor CD28 as unimodal population. MFI of PD-1 was analyzed for PD-1⁺CD8⁺ effector T cells. Horizontal bars represent population means. Mann−Whitney test was used for statistical analysis. *P < 0.05, **P < 0.01, ***P < 0.001. MFI median fluorescence intensity, FMO fluorescence-minus-one