Table 4.
Blood chemical analysis
| Parameters (unit) | Sex | Group | n | Period | |
|---|---|---|---|---|---|
| Baseline | Week 8 | ||||
| TP (g/dL) | Control | 19 | 7.1 ± 0.3 | 7.1 ± 0.3 | |
| Miso | 19 | 7.4 ± 0.2** | 7.3 ± 0.3† | ||
| Alb (g/dL)*1 | Control | 19 | 4.3 ± 0.2 | 4.3 ± 0.2 | |
| Miso | 19 | 4.5 ± 0.2* | 4.5 ± 0.2* | ||
| ALP (U/L)*1 | Control | 19 | 207 ± 87 | 201 ± 68 | |
| Miso | 19 | 204 ± 58 | 200 ± 60 | ||
| AST(GOT) (U/L)*1 | Control | 19 | 20 ± 6 | 20 ± 7 | |
| Miso | 19 | 20 ± 3 | 21 ± 4 | ||
| ALT(GPT) (U/L)*1 | Control | 19 | 19 ± 9 | 18 ± 8 | |
| Miso | 19 | 21 ± 9 | 19 ± 6 | ||
| γ-GTP (U/L)*1 | Male | Control | 15 | 32 ± 14 | 36 ± 22 |
| Miso | 13 | 38 ± 21 | 37 ± 27 | ||
| Female | Control | 4 | 34 ± 23 | 25 ± 24 | |
| Miso | 6 | 37 ± 30 | 36 ± 29 | ||
| TC (mg/dL) | Control | 19 | 207 ± 32 | 199 ± 36 | |
| Miso | 19 | 227 ± 31† | 219 ± 26† | ||
| TG (mg/dL)*1 | Control | 19 | 89 ± 42 | 93 ± 36 | |
| Miso | 19 | 112 ± 55 | 104 ± 40 | ||
| HDL-C (mg/dL) | Male | Control | 15 | 65 ± 15 | 61 ± 11 |
| Miso | 13 | 63 ± 20 | 58 ± 18 | ||
| Female | Control | 4 | 77 ± 21 | 70 ± 25 | |
| Miso | 6 | 59 ± 19 | 55 ± 15 | ||
| LDL-C (mg/dL) | Control | 19 | 119 ± 26 | 113 ± 33 | |
| Miso | 19 | 142 ± 27* | 138 ± 25* | ||
| BUN (mg/dL) | Control | 19 | 13.1 ± 2.5 | 13.6 ± 3.7 | |
| Miso | 19 | 12.8 ± 2.7 | 13.4 ± 3.1 | ||
| Cre (mg/dL) | Male | Control | 15 | 0.91 ± 0.10 | 0.90 ± 0.08 |
| Miso | 13 | 0.80 ± 0.11* | 0.82 ± 0.11* | ||
| Female | Control | 4 | 0.69 ± 0.05 | 0.67 ± 0.10 | |
| Miso | 6 | 0.61 ± 0.03* | 0.61 ± 0.03 | ||
| eGFR (mL/min/1.73 m2) | Control | 19 | 69.36 ± 2.09 | 69.92 ± 1.92 | |
| Miso | 19 | 79.45 ± 2.70** | 77.72 ± 2.62* | ||
| CKD G1/G2/G3 (subjects) | Control | 19 | 1/16/2 | 0/17/2 | |
| Miso | 19 | 3/15/1 | 3/15/1 | ||
| UA (mg/dL)*1 | Male | Control | 15 | 5.9 ± 0.7 | 6.1 ± 0.6 |
| Miso | 13 | 6.5 ± 0.5* | 6.6 ± 0.7† | ||
| Female | Control | 4 | 5.1 ± 1.1 | 5.2 ± 0.8 | |
| Miso | 6 | 4.6 ± 1.2 | 4.7 ± 1.2 | ||
| Na (mEq/L)*1 | Control | 19 | 141 ± 1 | 140 ± 1 | |
| Miso | 19 | 141 ± 1 | 141 ± 1 | ||
| K (mEq/L) | Control | 19 | 4.4 ± 0.2 | 4.4 ± 0.4 | |
| Miso | 19 | 4.3 ± 0.3 | 4.3 ± 0.4 | ||
| Glu (mg/dL)*1 | Control | 19 | 92 ± 9 | 88 ± 6 | |
| Miso | 19 | 90 ± 6 | 87 ± 8 | ||
| hANP (pg/mL)*1 | Control | 19 | 19.9 ± 10.4 | 16.3 ± 6.4 | |
| Miso | 19 | 13.3 ± 4.7 | 11.9 ± 5.9 | ||
TP total protein, Alb albumin, ALP alkaline phosphatase, AST (GOT) aspartate transaminase (glutamic-oxaloacetic transaminase), ALT (GTP) alanine transaminase (glutamic-pyruvic transaminase), TC total cholesterol, TG triglyceride; HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, BUN blood urea nitrogen, Cre creatinine, eGFR estimated glomerular filtration rate, CKD stage of chronic kidney disease, UA uric acid, Glu glucose, hANP human atrial natriuretic peptide. Values are expressed as mean ± standard deviation. The unpaired t-test and Mann–Whitney U test (*1) were used to evaluate between-group differences. †P < 0.1, *P < 0.05, **P < 0.01 vs control